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Uthsav Chitra

@uthsavc

Assistant Professor of Computer Science, Johns Hopkins University @JHUCompSci @HopkinsDSAI working on computational genomics + ML
Baltimore, MD chitra-lab.github.io Joined September 2018
596 Following 1.1K Followers 443 Posts

Latest posts 5

Uthsav Chitra @uthsavc
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Albert Gu Verified account @_albertgu Oct 28
I've always believed that intelligence should come from simple, general building blocks that learn their own abstractions directly from raw data; in other words, the bitter lesson. I think we're finally seeing a real step towards AI that can learn from all data.

Language modeling on raw bytes is a microcosm of this ideal, and to me it's a central problem in AI: if we can't build LLMs that learn end-to-end from bytes, how will we handle the rest of the world's data that we understand even less?

Last year we introduced hierarchical networks (H-Nets) as a first step. Our new version finds up to 3-5x efficiency gains in controlled scaling law experiments, and at larger scale matches an open-source model trained on 11T tokens with ~10x less data and compute. The posts below walk through what we found and why we think it works.
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Uthsav Chitra @uthsavc
Do spatial transcriptomics foundation models (SFMs) actually learn biologically meaningful spatial patterns? 🧬

Excited to share our new work assessing if current spatial foundation models learn multi-scale spatial variation in gene expression (spoiler: mostly no)
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Uthsav Chitra @uthsavc
New postdoc opportunity at JHU!

If you're interested in doing a postdoc with me or others at JHU, apply here.
Join us in advancing data science and AI research! The Johns Hopkins Data Science and AI Institute Postdoctoral Fellowship Program is now accepting applications for the 2026–2027 academic year. Apply now! Deadline: Jan 23, 2026. Details and apply: apply.interfolio.com/179059
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Uthsav Chitra @uthsavc
an elegant and extremely efficient (method-of-moments) test for epistasis in human traits

congrats Boyang, Ali et al!! super excited to see this work published 🙂
Boyang Fu Verified account @Boyang1995 Dec 9, 2025
🧬 Do genetic variants interact in humans?

For years, the answer was “probably, but we lacked solid statistical evidence.” We now bring one of the strongest pieces of evidence to date.

Thrilled to share our latest work, FAME, now at Nature Genetics: nature.com/articles/s4158…
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