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Perspective outlining multiple entry points for studying the molecular basis of human brain evolution with @TylerFair_ sciencedirect.com/science/articl…
Latest posts 5
1/ Our new study, led by @ding5066, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification
nature.com/articles/s4158…
nature.com/articles/s4158…
www.nature.com Dissecting gene regulatory networks governing human cortical cell fate Nature - Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional... Excellent study from @gauravsinghrat using stem cell-derived neural tube models to study regionalization and cell fate:
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
www.biorxiv.org Mapping early patterning events in human neural development using an in-vitro microfluidic stem... Stem cell models can provide insights into human brain development at embryonic stages which are normally inaccessible. We previously developed the Microfluidic Stem Cell Regionalisation (MiSTR)... Introducing CellBouncer, a unified demultiplexing toolkit built by @nkschaefer87 to check IDs and keep the riff raff out of single cell genomics datasets, including by using genetic variation as an external ground-truth for ambient RNA removal:
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Pleasure to co-edit this issue of Current Opinion on human genetic origins with @jsteinlab with support from @ELS_Genetics :
sciencedirect.com/special-issue/…
sciencedirect.com/special-issue/…