@bsadamson
Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.View quoted post on X
Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.View quoted post on X
www.addgene.org pCMV-PE7 Plasmid pCMV-PE7 from Dr. Brittany Adamson's lab contains the insert PE7 and is published in Nature. 2024 Apr 3. doi: 10.1038/s41586-024-07259-6. This plasmid is available through Addgene. Excited to share with you our manuscript describing the endogenous protein La as a mediator of prime editing and the development of our PE7 editor, which can improve prime editing. For more, please check out nature.com/articles/s4158…View quoted post on X
