What a day for the most heavily shorted names in SMID-cap biopharma following the $MRNA news and price action today.View quoted post on X
Hard not to think we saw some meaningful short covering / forced de-grossing across specialist books, with crowded shorts getting squeezed almost indiscriminately. Some pretty remarkable moves across the group.
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Steven Dickman 🇺🇦
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Founder-CEO of CBT Advisors, a life sciences consultancy. Former venture capitalist w TVM Capital, fmr reporter Nature, Economist. Also @cbtadvisors.bsky.social
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The move in $MRK wasn’t bad either $135 —> $152.
$MRK outsized move on Ph3 topline for results in melanoma highlight investor recognition Merck is pivoting from an LOE to a long-term, durable growth story.revisit core MRK thesis, pipeline outlook and peak-sales assumptions across portfolio. upwardly revise our pipeline peak sales +3bn reflecting increased program confidence & see room for upside on 2026-27 catalyst pathView quoted post on X
I knew it was big but… wow. $MRNA
Not just the biggest $ move in the history of biotech, but also the biggest % move in the history of the S&P500!View quoted post on X
By a very wide margin too, and nearly 2 decades since the distant 2nd place had its day in the sun.
Good to see data backing up that this $MRNA move was actually as crazy as it felt!
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Indeed. $PMN stock, however, has been a dud.
These early $PMN safety data — 4% total ARIA rate — should get attention today:View quoted post on X
ProMIS preliminary trial results suggest a path to a safer Alzheimer’s treatment statnews.com/2026/07/28/pro…