Minhui Chen

@chen_cmh

Assistant Professor in Statistical Population Genetics @VCU_VIPBG | Former Postdoc at @UChicagoMed @usc_cge.

sites.google.com/view/minhui-ch… Joined July 2015

923 Following 429 Followers 230 Posts

Latest posts 5

CIGMA is out in Nature — A linear mixed model to unbiasedly characterize cell-type-specific eQTLs. Work advised by @andywdahl and a lot of help from @xinpei_w
nature.com/articles/s4158…

www.nature.com Cell-type-specific eQTLs underlie the genetic architecture of complex traits Nature - Single-cell RNA-sequencing shows that cell-type-specific expression quantitative trait loci drive much of complex trait heritability, highlighting cell-type-specific gene regulation as key...

Minhui Chen @chen_cmh Feb 28, 2023

New preprint!
Together with @andywdahl , we develop CTMM (Cell Type-specific linear Mixed Model), a novel method for scRNA that detects cell type-specific gene expression from a new angle compared to standard tests for Differentiatlly Expressed Gene (DEG). biorxiv.org/content/10.110…

www.biorxiv.org A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data The development of single-cell RNA sequencing (scRNA-seq) offers opportunities to characterize cellular heterogeneity at unprecedented resolution. Although scRNA-seq has been widely used to identify...

Minhui Chen @chen_cmh Oct 2, 2020

With @CharlestonCWKC Second piece on polygenic adaptation on human height is out. We confirmed signals among global populations using UKB and BBJ. Thanks for help and comments from Jing Guo and @jyang1981 biorxiv.org/content/10.110…

www.biorxiv.org Allele frequency differentiation at height-associated SNPs among continental human populations Polygenic adaptation is thought to be an important mechanism of phenotypic evolution in humans, although recent evidence of confounding due to residual stratification in consortium GWAS made studies...

Minhui Chen @chen_cmh Jun 12, 2020

Thanks @AJHGNews! Our first piece on polygenic adaptation on height is out! Compared to preprint, our main conclusions didn't change though there were more refined analyses after extensive discussions in review. AD Times: sec piece on this topic will be on ASHG 2020 (hopefully)!

AJHG @AJHGNews Jun 12, 2020

There's a lot to think about regarding polygenic adaptation. @CharlestonCWKC & colleagues present evidence for an adaptive signature at height-associated loci bit.ly/3hgElR7

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Minhui Chen @chen_cmh Sep 20, 2019

Really excited to share my first project on Human Genetics "Evidence of polygenic adaptation at height-associated loci in mainland Europeans and Sardinians" with @CharlestonCWKC . biorxiv.org/content/10.110… (1/6)

www.biorxiv.org Evidence of polygenic adaptation at height-associated loci in mainland Europeans and Sardinians Adult height was one of the earliest putative examples of polygenic adaptation in human. By constructing polygenic height scores using effect sizes and frequencies from hundreds of genomic loci...