PGSC, a new method from my student Renée Fonseca, shows that gene-context interactions can robustly improve prediction. PGSC gains can be large, replicate across ancestries and cohorts, and largely survive on the log scale, unlike PGS amplification. biorxiv.org/content/10.648…
www.biorxiv.org Locus-specific gene-context interactions improve polygenic prediction Polygenic scores (PGS) are a primary output of large-scale genetic studies and are being deployed in clinical and non-clinical settings. However, current PGS assume simple additive models that ignore... 
