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Colin Sparano

@csparano93

Postdoc @ReiseSousaLab🔬 @TheCrick | Immunologist with focus on NK cells, DCs and Tumorimmunology
London, England crick.ac.uk/research/labs/… Joined February 2017
269 Following 211 Followers 62 Posts

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Colin Sparano @csparano93
Excited to share our new paper in @JExpMed 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence. rupress.org/jem/article/22…
rupress.org Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells Sparano et al. show that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. In these environments
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Colin Sparano @csparano93
Widely-used drug Azathioprine causes suprsingly selective loss of NK cells and Th1 impairment, with patients suffering from frequent herpes virus re-activations. Check out our paper: jacionline.org/article/S0091-…
www.jacionline.org Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to... Azathioprine is a widely prescribed drug for patients with chronic inflammatory diseases such as myasthenia gravis or organ transplant recipients. Azathioprine exerts immunosuppressive effects by...
Colin Sparano @csparano93
Excited to share our paper on ILC1 and NK cell ontogeny. Embryonic ILC1s persist and mature in the liver, forming cytotoxic effectors - postnatal wave brings first NK cells and more ILC1s. Now in @SciImmunology

science.org/doi/10.1126/sc…
www.science.org Embryonic and neonatal waves generate distinct populations of hepatic ILC1s Characterization of murine group 1 ILC development reveals a layered ontogeny influenced by tissue and age.
Colin Sparano @csparano93
Thanks, Georg! Very much enjoyed to work with you and Christin!
Georg Gasteiger @GeorgGasteiger Sep 2, 2022
Ontogeny: 2 waves of hepatic ILC1s - embryonic cytotoxic cells coexist with the full spec of Hobit-dependent ILC1s emerging postnatally. Thanks for this great collaboration with Colin @csparano93 and Sonia Tugues @UZH_en and @Becherlab now @SciImmunology science.org/doi/10.1126/sc…
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