Corey Howe

@design_proteins

customer success @adaptyvbio, agentic protein design @peptai_, building @seqdesign, exploring bioengineering, inspired by evolution and biosolutions

seq.design Joined February 2009

736 Following 1.5K Followers 899 Posts

Latest posts 5

Corey Howe @design_proteins Nov 4

fragrant proteins via odorant binding and inducible release

load protein with fragrance, apply to skin, induce fragrance release with sweat or other trigger

could be engineered for different fragances or triggers

sciencedirect.com/science/articl…

Corey Howe @design_proteins Nov 3

Optimizing a peptide binder hit to a small molecule hit while retaining potency

Very cool results, haven't seen anything like that before

Amazing speed and iteration by the Capable team
progress.capable.com/p/202610

Corey Howe @design_proteins Oct 29

Prompt to Binders with BindClaw!

Yehlin Cho Verified account @ChoYehlin Oct 29

🚀 Excited to share BindClaw! 🦀

Starting from a prompt or research paper, BindClaw connects biological mechanisms to protein design: identify targets and binding sites → build mechanism-specific computational assays → generate and assess binders → refine designs using the results.

We use agents to evaluate whether designs fit the intended biological objective, including competition with a native partner and preference for a particular molecular state. 🧬

In a human-guided calmodulin campaign, 15 of 18 designs showed binding to calcium-loaded CaM, including subnanomolar binders supported by both BLI and SPR.

This work is an incredible team effort together with @DidiKieran , @saint__ai, @ Kyle Gion and @sacdallago and many others!

📄paper/project: research.nvidia.com/labs/dbr/asset…
💻code: will be released in a few weeks!

View quoted post on X

Corey Howe @design_proteins Oct 29

It feels like we are in a biotech goldrush

New tools, new understanding, new data, new methods, all of scientific literature at our fingertips

But it also feels like there is still something holding back a true exponential

Biotech is just too expensive

Corey Howe @design_proteins Oct 27

From protein engineer to
protein designer to
protein developer to
protein architect to
protein maestro to
protein composer to
protein prophet to
protein oracle to
protein messiah to
protein deity