Elliot Tapper

@ebtapper

Hepatologist @michiganliver @vaannarbor; #cirrhosis; encephalopathy; frailty; quality improvement; father; husband. #livertwitter Co-EIC of @HepCommJournal

Ann Arbor, MI uofmhealth.org/profile/4313/e… Joined September 2011

656 Following 43K Followers 16K Posts

Latest posts 5

Elliot Tapper @ebtapper 15m

Treat HBV with normal ALT (<40 U/L)?

PROMOTE randomized 193 such pts to Tenofovir amibufenamide (TMF) vs no treatment: 82% on TMF had HBV DNA <20 IU/mL at Wk144, and 9 untreated controls progressed to meet treatment criteria.
#MedlQTLM26
#HBV

Elliot Tapper @ebtapper 19m

Repurposing a prevention vaccine as therapy?

Phase 1: 2 doses of TLR9-adjuvanted HbSag (HEPLISAV-B_ in 10 NUC-treated pts with HBV were safe, HBsAg fell modestly (0.1–0.5 log) in 8, and anti-HBs rose in 2. #MedlQTLM26 #HBV

Elliot Tapper @ebtapper 20m

Hep B treatment is getting cool
Meet SA1211. It silences HBV transcripts AND PD-L1.
Phase 1 trial: 150 mg x3 doses lowered HBsAg 0.73 log by Wk8, and exhausted CD8+ subsets fell 37–70%.
#MedlQTLM26 #HBV

Elliot Tapper @ebtapper 21m

Good flares? The immune system is a frienemy!

ALT flares on bepi in the B-Well trials (ALT =3x baseline) had faster, deeper HBsAg decline, and most functional-cure responders had one.

#MedlQTLM26 #HBV

Elliot Tapper @ebtapper 24m

Can lowering viral antigen wake up HBV immunity?
After 96 wks of Pevifoscorvir (ALG-000184), a capsid assembly modulator (CAM-E), HBeAg+ pts showed less T/NK-cell exhaustion, fewer Tregs and detectable HBV-specific T cells.
#MedlQTLM26
#HBV