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Eterna

@eternagame

Eterna is a videogame where you can invent medicine. You solve RNA design puzzles, and your solutions get synthesized and tested by biochemistry & robotics!
Stanford, CA eternagame.org Joined October 2010
225 Following 1.1K Followers 954 Posts

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Eterna @eternagame
We made the cover of Science! Congratulations to all the players and researchers who worked so hard on the OpenKnot project the last two years.
Science Magazine Verified account @ScienceMagazine Aug 27
On the citizen science platform Eterna, #AI methods matched expert human players at inventing sequences that fold into an RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule.

This opens a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch.

Learn more this week in Science: scim.ag/4wPnPwM
Each diagram is a designed RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule. On the citizen science platform Eterna, artificial intelligence methods matched expert human players at inventing sequences that fold into these shapes, opening a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch. Image: J. Townley et al., Science 393 , 931 (2026); Adapted by N. Jessup/Science
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Eterna @eternagame
Our Replicase pilot results found that the catalytic activity and copyability of the 71-89 polymerase ribozyme can be improved! We have launched a new puzzle for finding a version that excels at both properties simultaneously. Comp methods are encouraged to submit designs!
Puzzle interface displaying both the secondary and tertiary structure of the ribozyme