Excited to share my latest first-author manuscript, now available as a preprint on @biorxiv_immuno! We introduce VLP-Open HLA, a new protein-based nanoparticle platform for T-cell screening studies, leveraging SpyTag/SpyCatcher bioconjugation chemistry and engineered open MHC-I!
Tired of running separate experiments using ELIspots and tetramers? Then use VLP-Open HLA - a versatile nanoparticle platform that can screen for #Tcell responses in vitro. Using SpyTag/SpyCatcher chemistry to conjugate our loadable, open #MHC-I molecules on engineered protein-based nanoparticles, our platform can efficiently detect and activate antigen-specific T cells at scale.
tinyurl.com/2m9pdjj7
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