SgourakisLab

Great week at the 2026 Gordon Research Conference-The #Immunopeptidome in Health and Disease! Wonderful to see the latest developments in all aspects of #MHC antigen processing and presentation and to share our work with this incredible community.
Thanks to all the organizers and participants for the inspiring discussions! #StructuralImmunology @PennMedicine @BMBGGUPENN @CHOP_Research @CancerGrand

From cold to hot tumors: Our lab's first 2026 paper in @ScienceAdvances: HLA-Shuttle restores antigen presentation in "cold" tumors like neuroblastoma, enabling discovery of hundreds of new therapeutic targets to guide #Immunotherapy development.
Great team effort led by Daniel Hwang with collaborators John Maris, @MustafaMir16, Andrea Facciabene and Alithea Bio.
Supported by @CancerGrand Teams NexTGen&MATCHMAKERS,@theNCI @TheMarkFdn @UPenn_I3H @PennMedicine @CHOP_Research
tinyurl.com/3uechppk

What are the structural features driving #HLA restriction of T cell receptors? This comprehensive analysis of interactions by @SagarGupta047 provides a classification system of polymorphic HLAs from different patients to inform the expansion of T cell-based therapies. Supported by @CancerGrand Teams MATCHMAKERS, NexTGen

Just out in @PNASNews ! Using the @UWproteindesign's SMART #MHCI concept we can now rapidly map interactions with #Tcell receptors by #NMR. This could accelerate immunotherapy development for #CancerGrandChallenges Teams MATCHMAKERS, NexTGen. Congratulations to @chw1228 and all the authors! @CancerGrand @TheMarkFdn @theNCI @CHOP_Research
tinyurl.com/2jpnr7zj

🎓Celebrating a major milestone: Two outstanding new PhDs, Drs. Yi Sun and Claire Woodward graduated in the 2025 @pennbgs ceremony-our lab's very first graduates from @BMBGGUPENN. We are all incredibly proud of their dedication and accomplishments. The future of science is bright with minds like these!