Jesse Engreitz

@jengreitz

Assistant Professor @stanford Genetics and BASE Initiative. Mapping the regulatory code of the human genome to understand heart development and disease.

Stanford via Broad/MIT/Harvard engreitzlab.org Joined August 2010

420 Following 3.9K Followers 1K Posts

Latest posts 5

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Jesse Engreitz @jengreitz Feb 7, 2024

Our latest in @Nature:

Convergence of coronary artery disease genes on endothelial cell programs

nature.com/articles/s4158…

Incredible work led by Gavin Schnitzler and @kanghelenyihua — a long-standing partnership between our lab and @Dr_RajatGupta

My comments below:

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www.nature.com Convergence of coronary artery disease genes onto endothelial cell programs Nature - Variant-to-gene-to-program is a new approach to building maps of genome function to link risk variants to disease genes and to convergent signalling pathways in an unbiased manner; its...

Jesse Engreitz @jengreitz Nov 7

Our latest preprint:

• Improved split-pool Perturb-seq method
• Gene programs in hiPSC-endothelial differentiation
• New role for Hippo pathway in vitro and in vivo
• Strategy for improving differentiation by faking cell density

biorxiv.org/content/10.648…

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Jesse Engreitz @jengreitz Oct 14

Every field needs its own @epigenetichulk

Thank you @anshulkundaje for your service :)

Anshul Kundaje @anshulkundaje Mar 18

If u want to prove that ur models are learning biology, SHOW IT! SHOW US THE KNOWN AND NOVEL REGULATORY LOGIC AND PHENOMENA YOUR MODELS ARE UNCOVERING! 27/
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Jesse Engreitz @jengreitz Oct 9

Check out Swap-seq — our next-gen tech for tiled twin prime deletion mapping of distal regulatory elements

biorxiv.org/content/10.6...

Please get in touch if you’d like to try it out!

Thread 👇

Xiangmeng(Shawn) Cai @XiangmengCai Oct 9

Have you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question.
biorxiv.org/content/10.648…
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Jesse Engreitz @jengreitz Sep 9

Correlation, sadly, is not the answer

Ben Kuznets-Speck @benkuznetsspeck Sep 8

Several groups are now converging on a surprisingly simple idea in perturbation biology: how cells fluctuate before a perturbation tells us how they will respond after it.
That idea is the starting point of CIPHER.

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