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I'm delighted to release the first half of my new open-access online textbook in human population genetics:
web.stanford.edu/group/pritchar…
web.stanford.edu/group/pritchar…
Jonathan Pritchard
@jkpritch
My lab at Stanford studies human population genetics and complex traits.
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Latest posts 5
Unexpected meanings of the term TWAS!
New preprint alert: we use sign errors as a test of how well TWAS works.
Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS.View quoted post on X
In a new pre-print with @PGerlach98341, Jeff Spence, and @jkpritch, we find that TWAS gets the sign wrong around 20-30% of the time!
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I'm delighted to announce our new preprint on genome-scale perturb-seq in CD4 T cells. We learned general lessons about the power of perturb-seq, and specific lessons in T cell biology
Led by amazing postdocs Ronghui Zhu and Emma Dann with my wonderful collaborator Alex Marson
Led by amazing postdocs Ronghui Zhu and Emma Dann with my wonderful collaborator Alex Marson
Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs.
🧵👇View quoted post on X
Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful Jon Judd, and co-mentored by Jeff Spence.
This work is by the wonderful Jon Judd, and co-mentored by Jeff Spence.