Fantastic new preprint from @lesloew!!
Check our our new preprint. Combining measured solution rate constants and structural data to estimate bimolecular rate constants at membranes.
biorxiv.org/content/10.110…View quoted post on X
Jonathon Ditlev
@Jonathon_Ditlev
Assistant Professor of Biochemistry at the University of Toronto. Opinions are my own.
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Latest posts 5
Preprint alert from the @Jonathon_Ditlev Lab! In this study led by postdoctoral fellow Leshani Liyanage, we discovered that missense mutations in the IDR of shank2 results in increased condensate elasticity and altered composition and function.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
www.biorxiv.org Disease-linked mutations dysregulate neuronal condensate physical properties, composition, and RNA... Local RNA translation is essential for development. In neurons, deficient local translation linked with mutations in scaffold proteins results in dysregulated dendrite and dendritic spine growth.... In this study in MBoC, @AniChattaraj and Zeynep Baltaci spearhead our efforts (w/ @lesloew & Bruce Mayer) to develop methods to quantitatively understand and predict phase separation of multivalent binding partners using computational modeling and precise quantitative microscopy
From MBoC
Computational models & biochemical experiments show that the solubility product (the concentration of dilute phase proteins) is predictive of phase separation in multicomponent systems that employ heterotypic & homotypic... @jonathon_ditlev
doi.org/10.1091/mbc.E2…View quoted post on X
Led by @yimeiwan together with Jordyn Smith, Rhea Hudson, and Julie Forman-Kay, we investigate the biophysical mechanism for CFTR cluster formation on membranes. We find that clusters of CFTR are consistent with phase separated condensates.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
www.biorxiv.org Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on... The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel whose dysfunction leads to intracellular accumulation of chloride ions, dehydration of cell surfaces, and subseq... This will be an excellent symposium! Thank you @stromgaardlab for organizing it and for the invitation to share our work!
We are very happy to announce our symposium on #bimolecular #condensates - June 11 in Copenhagen. Presentations by Alex Büll, @Jonathon_Ditlev, Mingjie Zhang, @ProteinMagnus, @mz_science and Michael Wagner @dewpoint_txView quoted post on X
