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Kenneth Loi

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@kenjmloi

Decoding life's longest war
Doudna Lab @UCBerkeley
Berkeley, CA kennethloi.com Joined January 2020
2K Following 1K Followers 549 Posts

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Kenneth Loi Verified account @kenjmloi
VIPR is now out in @ScienceMagazine!

What started with a mysterious RNA led us to an unexpected way of recognizing DNA, as well as some clues to CRISPR’s origins.

So happy to share these two papers with an incredible team. Links below; original discovery thread here ↓
Kenneth Loi Verified account @kenjmloi Apr 27
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.

We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.

Thread + link below.
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Kenneth Loi Verified account @kenjmloi
Devil’s in the details. We stand on the shoulders of the OGs who did the careful characterizations of each of these gene families
owl Verified account @owl_posting Oct 26
in the fullness of AGI, the 2500 citation cell atlas papers will have been far less useful to the models compared to every single "lessons learned from [x]" paper
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Kenneth Loi Verified account @kenjmloi
Favorite line:
"This strategy enables satellite collusion with its host to
prevent virus-borne VIPR targeting that would otherwise
prevent satellite propagation."
Kenneth Loi Verified account @kenjmloi Oct 18
Viruses have parasites too. Our new preprint shows how phages use VIPR to silence parasitic satellites, and how the satellites fight back with its own decoy VIPR RNAs that redirect VIPR to DNA REP elements in the host genome!!
biorxiv.org/content/10.648…
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