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Kerrin Small

@kerrin_small

Professor at King's College London
London, UK Joined November 2012
203 Following 257 Followers 66 Posts

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Kerrin Small @kerrin_small
Our paper on longitudinal multi-omics in an aging population is out at @ScienceMagazine

Led by @Julia_Moustafa , we profiled gene expression and metabolomics at 3 timepoints in 335 individuals over 6-8 years to investigate molecular aging trajectories
science.org/doi/10.1126/sc…
www.science.org Longitudinal dynamics of gene expression and metabolomics in an aging population cohort Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longit...
Kerrin Small @kerrin_small
Very excited to share that our manuscript on cis-eQTL analysis of adipose tissue gene expression in 2,344 samples is now out in Nature Genetics
rdcu.be/d5ov4

See thread from lead author @SarahBrotman below
Sarah Brotman @SarahBrotman Jan 7, 2025
I’m excited to share that this manuscript is now published in Nature Genetics! 🧪🧬 🖥️

nature.com/articles/s4158…

The AdipoExpress data can be accessed here: zenodo.org/records/138451…

An interactive browser of the colocalization results can be accessed here: adipose.colocus.app
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Kerrin Small @kerrin_small
Our paper led by @anto_zito investigating variation in escape from X-inactivation across tissues, individuals and twin pairs is now published in @PlosGenetics dx.plos.org/10.1371/journa…

Many thanks to @A_L_Roberts @_alesssia @Julia_Moustafa @MarioFalchi @TwinsUKres
journals.plos.org Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues... Author summary The difference in the number of X-chromosomes between mammalian males and females is compensated by a process known as X-chromosome inactivation (XCI), which turns off one of a...
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Kerrin Small @kerrin_small
Our paper led by @A_L_Roberts on skewed X chromosome inactivation and its relationship with molecular and cellular measures of aging, cardiovascular disease risk, and cancer diagnoses is online at @elife
doi.org/10.7554/eLife.…
elifesciences.org Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans Prospective, cross-sectional, and intra-twin study designs identify skewed X chromosome inactivation is associated with cardiovascular disease risk and future cancer diagnosis in the TwinsUK popula...