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King L Hung

@kinglhung

Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.
San Diego, CA kinglhung.org Joined February 2015
152 Following 1.2K Followers 408 Posts

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King L Hung @kinglhung
Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
nature.com/articles/s4158…
www.nature.com Genetic elements promote retention of extrachromosomal DNA in cancer cells Nature - A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies...
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King L Hung @kinglhung
This was probably one of my crazier ideas early in grad school and was such a fun project to work on. Check out this awesome short video from @JuliaBauman2 highlighting this work!
Julia Bauman Verified account @JuliaBauman2 Dec 3, 2025
ecDNA biology is one of those weird, fascinating corners of bio that hook me every time there's a new result. So I loved reading about this one from @HowardYChang & Paul Mischel's labs in @Nature.

Very interesting implications for design of non-diluting, non-integrating gene therapy vectors!

Great work Venkat & @kinglhung 😀
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King L Hung @kinglhung
Nice feature article from @_eunhee_yi_ and Noah Dusseau about our work: nature.com/articles/d4158…
King L Hung @kinglhung Nov 19, 2025
Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
nature.com/articles/s4158…
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