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Excited to share new work from our lab in Nature Communications! 🚀
We uncover how UFC1 — an E2 enzyme without the classic HPN motif — stabilizes critical oxyanion intermediates.
🔗 doi.org/10.1038/s41467…
www.nature.com UFC1 reveals the multifactorial and plastic nature of oxyanion holes in E2 conjugating enzymes Nature Communications - Oxyanion stabilization is essential for E2 enzyme activity in ubiquitin and Ub-like protein conjugation. Here, the authors demonstrate that E2 enzymes (1) employ C-alpha... Excited to share new work from our lab in Nature Communications! 🚀
We uncover how UFC1 — an E2 enzyme without the classic HPN motif — stabilizes critical oxyanion intermediates.
🔗 doi.org/10.1038/s41467…
