Michael Polansky

When we introduced @OuterBio, we shared Yuna, the platform we spent the last several years building to keep real human skin alive and measurable long enough to study the biology that unfolds over time.

This week, Advanced Science published our peer-reviewed study validating Yuna’s ability to keep human skin alive and measurable for over four weeks.

That extended window allows us to measure how skin actually functions over time, capturing complex processes like chronic inflammation, cellular senescence, and responses to environmental stress that shorter-duration models cannot fully reproduce.

Read the full paper in the comments.

We've spent the last several years building what we believe is the best instrument for studying human skin. Real tissue, alive and measurable long enough to see skin change the way it does in the human body. Our goal is to meaningfully improve skin health. We hope you'll follow along.

techcrunch.com/2026/08/21/mic…

I'm excited to introduce @OuterBio and Yuna, the ex vivo human skin platform our team has been building for the past several years. Yuna keeps living, full-thickness human skin viable and observable for four weeks, with native tissue architecture preserved.

Innovation in skin health has been slow for decades, and part of the reason is that outside the body, human skin has only stayed usable for about a week. Yet key biological processes such as collagen rebuilding, inflammation resolution and damage accumulation take far longer than that. The field has been reading the opening days of a process that plays out over a month.

Yuna extends that window and pairs it with machine learning in a closed loop, so every experiment sharpens the next prediction.

Our bioRxiv preprint shows Yuna holding three distinct skin biologies across four weeks: psoriasis-like inflammation, senescence in aged donor tissue, and UVB stress response. In each case it returned the known answer when challenged with an established intervention.

Thank you to KJ Jang, Chris Hinojosa, Stan King, and the rest of the incredible Outer Bio team.

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