Mirco J. Friedrich

@mircoscopy

Physician Scientist | Feng Zhang Lab @broadinstitute & @MIT | @EMBO Fellow
Decoding and engineering human immunity | 🇩🇪🇫🇷🇪🇺🇺🇸

Cambridge, MA Joined March 2023

96 Following 592 Followers 74 Posts

Latest posts 5

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Mirco J. Friedrich @mircoscopy Apr 10, 2023

My first cover story in this month's issue of @Cancer_Cell! 🍾

"On the cover: Friedrich et al. (711–725) reveal the mode of action of bispecific antibodies in patients with multiple myeloma."

Check it out:
cell.com/cancer-cell/cu…
cell.com/cancer-cell/fu…

Mirco J. Friedrich @mircoscopy Jan 3, 2025

One step more towards non-immunogenic genome editing 🚀
Using AI-informed epitope mapping, we engineered effective #CRISPR nucleases with reduced immunogenicity. This paves the way for safer, repeatable genome therapies in humans.
bit.ly/redicas9

Mirco J. Friedrich @mircoscopy Sep 23, 2024

Happy to have contributed to this intelligent next step in building better mRNAs for therapeutic application!
Check it out:
nature.com/articles/s4158…

www.nature.com Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation Nature Biotechnology - mRNA cap designs boost translation >10-fold, with potential benefits for RNA therapies.

Xiao Wang Verified account @WangXiaoLab Sep 23, 2024

Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX

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Mirco J. Friedrich @mircoscopy Jul 15, 2024

Honored to receive this Young Investigator Award for novel immunotherapy approaches against brain tumors. Thanks so much to my graduate institutes @DKFZ and @uniklinik_hd for their support! 🎉 #brain #cancer #glioma #immunotherapy

DKFZ @DKFZ Jul 15, 2024

Neue Therapieansätze gegen #Hirntumor|en: Gips-Schüle-Nachwuchspreis 2024 für Mirco Friedrich (#DKFZ und @uniklinik_hd). Herzlichen Glückwunsch! 👏
➡️ t1p.de/d8b8n

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Mirco J. Friedrich @mircoscopy May 3, 2024

Excited to share our latest publication in @SciImmunology! We've uncovered an NK cell-mediated immune checkpoint (B7H6 : NKp30) that limits CAR T cell persistence, revealing new insights into immune regulation. #Immunology @broadinstitute @DKFZ
science.org/doi/10.1126/sc…