Davide Pisu

@mtbmeds

Professor 🥼🎓| Host-pathogen interactions w/ M. tuberculosis 🦠 | Macrophages 🔬 | Infectious diseases 🧫 | Soccer ⚽ & F1 🏎️ enthusiast!

Joined June 2021

1.9K Following 2.2K Followers 94 Posts

Latest posts 5

Davide Pisu @mtbmeds Mar 23, 2025

apnews.com/article/tuberc…
Tuberculosis cases in the US rose to their highest levels in more than a dozen years.

apnews.com Tuberculosis cases in the US rose to their highest levels in more than a dozen years Tuberculosis continued to rise again in the U.S. last year, reaching its highest levels in more than a dozen years.

Davide Pisu @mtbmeds Feb 13, 2025

North Carolina tuberculosis cases rising for first time in decades following one of the worst outbreaks in U.S. history

independent.co.uk/news/health/tu…

www.independent.co.uk North Carolina tuberculosis cases are on the rise for the first time in decades Cases of the world’s deadliest infectious disease have been increasing in the U.S. in recent years

Davide Pisu @mtbmeds Jan 7, 2025

Excited to share that our review on macrophage function and heterogeneity in tuberculosis infection is now published in Nature Reviews Immunology! We highlight key findings from recent studies including work from @AlissaRothchild @MikeAngeloLab @KhaderShabaana @WillingerLab @SteynTBLab @TobinLab @The_PW_Lab @patriciadarrah @CarlosMTBVAC @ElClubDarwin2 and many others!

Nature Rev Immunol @NatRevImmunol Jan 7, 2025

How macrophage heterogeneity affects tuberculosis disease and therapy go.nature.com/3DIKKEi
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Davide Pisu @mtbmeds Oct 31, 2024

Cool story from @nsimwela He developed a CRISPR-based genetic screen in Hoxb8 macrophages and found inhibition of the GID/CTLH E3 complex inhibits growth of Mtb and Salmonella. The GID complex is currently a drug target in cancer, so there is hope for potential new anti-TB drugs.

Nelson V. Simwela, PhD @nsimwela Oct 29, 2024

First story from my postdoc in the Russell lab @cornellvet out today in @NatureComms. We performed a genome wide CRISPR knockout screen in primary macrophages and identified the 12 member GID/CTLH proteosomal complex as a negative regulator of intracellular bacterial growth.
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Davide Pisu @mtbmeds Oct 2, 2024

Happy to share our new work “The frequency of CD38+ alveolar macrophages correlates with early control of M.Tuberculosis in the murine lung” is finally out in @NatureComms . @Mattila_TB_Lab @LuanaJohnston13 with support from @CornellCFI @CornellGenomics nature.com/articles/s4146…

www.nature.com The frequency of CD38+ alveolar macrophages correlates with early control of M. tuberculosis in the... Nature Communications - Mycobacterium tuberculosis infection remains a global health crisis. Here researchers characterise the alveolar macrophage subsets in a murine model of BCG vaccination in...