Michael V Holmes (he/him)

@mvholmes

Pharmaceutical physician & epidemiologist, MD/PhD Genentech. Opinions are my own.

Bay Area, USA linkedin.com/in/michael-vac… Joined May 2009

1.5K Following 1.8K Followers 4.4K Posts

Latest posts 5

Michael V Holmes (he/him) @mvholmes Jul 29, 2024

In a preprint from the @23andMeResearch team, we used Mendelian randomization to explore the genetically-predicted causal effects of Lp(a) on a range (n=489) of human traits and diseases.
medrxiv.org/content/10.110…

www.medrxiv.org Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide... Background Lipoprotein(a) (Lp[a]) is a circulating plasma lipoprotein that is emerging as an important independent risk factor for vascular disease. Lp(a) levels are 75-90% heritable, predominantly...

Michael V Holmes (he/him) @mvholmes Apr 5, 2024

A preprint from the 23andMe Research Team exploring the multi-ancestry genetics of diarrhea during acute Covid in which we find evidence that IBS subtypes influence risk.

Kudos to the 1st author, Ninad Chaudhary @ninaadsc, a postdoc in the Research Team!🙌medrxiv.org/content/10.110…

www.medrxiv.org Multi-ancestry GWAS of diarrhea during acute SARS-CoV2 infection identifies multiple novel loci and... A substantial proportion of acute SARS-CoV2 infection cases exhibit gastrointestinal symptoms, yet the genetic determinants of these extrapulmonary manifestations are poorly understood. Using survey...

Michael V Holmes (he/him) @mvholmes Mar 21, 2024

A preprint from the @23andMeResearch Team on the genetic architecture of sporadic and recurrent miscarriage and where we evaluate potential causal effects of modifiable exposures

TL;DR: we identify 11 novel GWAS loci and evidence smoking and caffeine potentially increase risk

medRxiv @medrxivpreprint Mar 21, 2024

Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage medrxiv.org/cgi/content/sh… #medRxiv
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Michael V Holmes (he/him) @mvholmes Jan 11, 2024

A new preprint from The 23andMe Research Team showcasing our capabilities in recall-by-genotype initiatives.
Here we use recall-by-genotype to facilitate enhanced phenotyping in order to characterise a LoF variant in MAP3K15 associated with T2D medrxiv.org/content/10.110…

Michael V Holmes (he/him) @mvholmes Nov 1, 2023

A preprint from our team showing that PRS can be used to identifying individuals with undiagnosed disease

medRxiv @medrxivpreprint Nov 1, 2023

A polygenic risk score identifies undiagnosed cases of diabetes medrxiv.org/cgi/content/sh… #medRxiv
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