Twitxy Saved

Philippe Batut

@philippe_batut

Long-range gene regulation: enhancers, noncoding RNAs
& 3D genome organization | Asst. Prof. @Columbia University
🦋 @philippebatut.bsky.social
New York, NY batutlab.com Joined January 2022
380 Following 351 Followers 83 Posts

Latest posts 5

Pinned post

Philippe Batut @philippe_batut
🧬🧪🔬Why are enhancers transcribed? How does it impact gene regulation? I’m excited to share our new paper in @ScienceMagazine showing that ncRNAs control the timing of gene activation in embryos. w/Mike Levine #ScienceResearch #RNA

A few highlights 🧵👇
science.org/doi/10.1126/sc…
www.science.org Noncoding transcription controls the developmental dynamics of long-range gene regulation The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely...
4 replies 65 reposts 256 likes 21K views View on X
Philippe Batut @philippe_batut
Thanks Katie @GallowayLabMIT, and congrats on your own very elegant paper! This is a great point, and transcription-induced supercoiling might very well be part of the story. There may also be some additional wrinkles in our system: [1/4]
Katie Galloway Verified account @GallowayLabMIT Sep 12
Nice work @philippe_batut ! This looks like eRNA priming with the upstream dominance we observed
We mapped this effect to supercoiling-mediated repression of the downstream gene. When the upstream gene turns off, then you can activate the downstream gene. Thread below.
View quoted post on X
1 replies 0 reposts 2 likes 1.6K views View on X