Sidi Chen

@sidichen

Gene editing. Technology. Cancer. Immunology. Cell and gene therapy. Antibody. mRNA vaccine. @ Yale Genetics & Systems Biology. ## CRISPR in vivo ##

New Haven, CT sidichenlab.org Joined December 2010

246 Following 1.2K Followers 54 Posts

Latest posts 5

Sidi Chen @sidichen 3d

11/4/2026
Excited to share our new Nature paper “In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs”. Led by Liqun, with Paul, Kaiyuan, Ariel. Also Tx to support from lab members and Markus, Stephen and Nidhi’s groups. Kudos team!
nature.com/articles/s4158…

www.nature.com In vivo CAR-T double knockout screen maps synergistic antitumour gene pairs Nature - Using high-throughput in vivo CAR-T double knockout screening, synergistic gene combinations to improve CAR-T cell therapy are revealed.

Sidi Chen @sidichen Feb 27

Excited to share our new Nature paper on in vivo CAR-NK CRISPRa screen + discovery of a hyperbooster for solid tumor nature.com/articles/s4158… Tx to Luojia, Paul, Drs Peng, Gunel, Moliterno, J Chen. #NK cell therapy @Yalegenetics @yalewestcampus @yalemed @yalecancer @yneurosurgery

www.nature.com OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours Nature - The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell...

Sidi Chen @sidichen Aug 26, 2025

Proud to share our new work at Nature biomedical engineering on mRNA vaccine platform innovation! nature.com/articles/s4155… @Carolina Lucas @zane_zhenhao Fang @Yale @YaleGenetics @YaleWestCampus

Sidi Chen @sidichen Jul 18, 2025

Proud to present our work at #KCRS25 on CAR-T screens, cell therapy and kidney cancer from @YaleMed @YaleGenetics @YaleWestCampus @YaleCancer Honored to be in session with Drs. Chuck Drake at JnJ, Nadal Rios at Hutch & Patrick Ott at Farber, hosted by David Braun &Hans Hammers.

Sidi Chen @sidichen Jun 17, 2025

Organizing an AI symposium on 6/20 with SAPA-CT at Yale. Please check it out and all are welcome to register/attend! @YaleWestCampus