Sabrina Simoncelli

@ssimoncelli

Assoc Prof in Nanoscale Characterisation interested in single-molecules, fluorescence, plasmonics, biophysics of immune cells. @LondonNanotech, @UCLChemistry

City of London, London simoncelli-lab.com Joined June 2010

591 Following 1K Followers 153 Posts

Latest posts 5

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Sabrina Simoncelli @ssimoncelli May 30, 2025

🚨 New paper alert! 🚨
Can we simultaneously achieve deep, high-res, large field-of-view imaging without the usual trade-offs? 🤔
🧬🔬 YES: #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC_OPR)! #SuperResolution
📄 nature.com/articles/s4146… @NatureComms 🧵👇

www.nature.com Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with... Nature Communications - Zaza and colleagues demonstrate that DNA-PAINT on a spinning disk confocal microscope with optical photon reassignment enables high-resolution imaging across large fields...

Sabrina Simoncelli @ssimoncelli Aug 5

Thrilled to see our work published today in @JCellBiol! 🎉

Congratulations to our fantastic first author @oliviapldalby. A huge thank you to the entire team: Efstratios Kirtsios, Hale-Seda Radoykova, @ceciliazaza, @MDJoseph97, Persis J. Amrolia, and @AGiustacchini.

Journal of Cell Biology @JCellBiol Aug 5

Olivia P.L. Dalby, Sabrina Simoncelli @ssimoncelli et al. use super-resolution imaging and reveal that CAR-T cells assemble immunological synapses with distinct actin architectures, including reduced central clearance and enhanced protrusions. hubs.la/Q04r-3kn0

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Sabrina Simoncelli @ssimoncelli Jun 9

New paper out in @SciSignal — and we made the cover! 🎉 We uncovered a new role for autoimmunity gene PTPN22 in shaping the T cell immunological synapse.

science.org/doi/10.1126/sc…

A thread 🧵 1/6

www.science.org PTPN22 regulates T cell synapse formation through PSTPIP1-dependent actin remodeling By preventing excessive T cell receptor clustering, the phosphatase PTPN22 dampens T cell activation.

Sabrina Simoncelli @ssimoncelli May 21

🎉 New paper out in @NanoLetters! Great @UCLChemistry team effort with @VijayChudasama_ & @BakerGroupUCL 🙌 We developed stoichiometrically defined antibody–DNA conjugates via pyridazinedione chemistry enabling truly quantitative super-resolution imaging with standard IgGs! 🧬🔬

Sabrina Simoncelli @ssimoncelli Feb 23

🚨 New JoVE protocol! 🚨
Want to achieve protein-level super-resolution across whole cells? 🧬🔬
Our #DNA_PAINT + Spinning Disk Confocal + OPR (#SDC_OPR) method is now step-by-step in @JoVEJournal
🎥 app.jove.com/v/69531/whole-…