Pinned post
Our latest manuscript is finally out in @NatureSMB!
Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels.
nature.com/articles/s4159…
Here, we show that the GAP activity of SEAC (GATOR) acts as a molecular switch, regulating both inhibition and reactivation of TORC1 upon changes in amino acid levels.
nature.com/articles/s4159…
www.nature.com Structure and function of the yeast amino acid-sensing SEAC–EGOC supercomplex Nature Structural & Molecular Biology - Tafur et al. determined the cryo-electron microscopy structure of the SEA complex (GATOR) bound to its substrate, the EGO complex (Ragulator–Rag),... 
