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Alexander van Oudenaarden

@AlexandervanOu1

Biophysicist, single-cell method developer, stem cell enthusiast, guitarist.
Utrecht, The Netherlands hubrecht.eu/research-group… Joined February 2020
53 Following 2.7K Followers 32 Posts

Latest posts 5

Alexander van Oudenaarden @AlexandervanOu1
VASA-seq: a wonderful collaboration with labs that generously contributed their expertise in microfluidics @hollfelderlab, splicing @m_hemberg and dev bio @AMartinezArias & Jennifer Nichols. 🙏Fredrik Salmen @JoachimDeJonghe @annionna @ge_parada @T_S_Kaminski for the heavy 🏋️‍♀️🏋️‍♂️⤵️
Joachim De Jonghe @JoachimDeJonghe Sep 16, 2021
Absolutely thrilled to share our VASA-seq pre-print on #biorxiv today: Droplet-based single-cell total RNA-seq reveals differential non-coding expression and splicing patterns during mouse development 🧵
biorxiv.org/content/10.110…
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Alexander van Oudenaarden @AlexandervanOu1
Our work on single-cell ribosome profiling is out! Huge congrats to @mvanins who was brave enough to embark on this pretty crazy experiment that turned out to work beautifully. Thank you @jervdberg, Amanda Andersson-Rolf and @HansClevers. Check it out: nature.com/articles/s4158…
www.nature.com Single-cell Ribo-seq reveals cell cycle-dependent translational pausing Nature - Highly sensitive ribosome profiling of single cells at single-codon resolution enables identification of distinct cell cycle-dependent translational dynamic states in individual cells.
Alexander van Oudenaarden @AlexandervanOu1
Excited to share our preprints on single-cell chromatin profiling. sortChIC (biorxiv.org/content/10.110…) to profile active and repressive histone modifications during blood formation. scChIX (biorxiv.org/content/10.110…) to map multiple histone modifications in the same single cells.
www.biorxiv.org Hierarchical chromatin regulation during blood formation uncovered by single-cell sortChIC Post-translational histone modifications modulate chromatin packing to regulate gene expression. How chromatin states, at euchromatic and heterochromatic regions, underlie cell fate decisions in...
Alexander van Oudenaarden @AlexandervanOu1
Congratulations @SusannevdBrink for an outstanding PhD defence today. I learned so much from you during your time in the lab. Thank you for bringing #gastruloids to our lab and all the best in Barcelona!
Alfonso Martinez Arias @AMartinezArias Nov 27, 2020
Congratulations @SusannevdBrink for defending (in The Netherlands the committee is ‘the opposition’) her PhD thesis, under @AlexandervanOu1's supervision, and passing w/ flying colours (cum laude). Wonderful work on #SatelliteCells #gastruloids #scRNAseq #Tomoseq #TourdeForce
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