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Lauren Hagler, PhD

@Cheers2LO

Assistant Professor in Chemistry at Texas A&M University | RNA chemical biology 🧬| HHMI Hanna Gray Fellow | #BlackinChem 👩🏾‍🔬#BlackinSTEM | she/her
College Station, TX haglerlab.org Joined March 2009
1K Following 1.2K Followers 8.4K Posts

Latest posts 5

Lauren Hagler, PhD @Cheers2LO
I'm very excited to announce #thehaglerlab 's new preprint now out on bioRxiv. biorxiv.org/content/10.648…
www.biorxiv.org Structural probing of RNA hairpins quantifies protein occupancy on RNA and links it to function in... RNA structures that form inside living cells influence processes ranging from translation to RNA decay, many of which are controlled by RNA-binding proteins (RBPs). Because RBP specificity depends on...
Abby Thurm @abbythurm Jan 7
How can we move toward a quantitative, predictive framework for how RBPs bind and regulate their RNA partners? In a new preprint @Cheers2LO @BintuLab, we show that structural profiling via DMS-MaPseq can be used to measure fractional occupancies of RBPs at single-base resolution.
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Lauren Hagler, PhD @Cheers2LO
Congrats, Abby on such an amazing piece of work and useful resource for the RNA community🧬 ! I can't wait to see the ways you and others use this technology in the future!!!
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)
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