Abby Thurm

@abbythurm

MD/PhD Student @StanfordMed | thinking about all things RNA in gene expression @BintuLab | B.S. @uclachem | she/her

Joined April 2020

429 Following 294 Followers 163 Posts

Latest posts 5

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Abby Thurm @abbythurm Jul 22, 2024

Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)

www.biorxiv.org High-throughput discovery of regulatory effector domains in human RNA-binding proteins RNA regulation plays an integral role in tuning gene expression and is controlled by thousands of RNA-binding proteins (RBPs). We develop and use a high-throughput recruitment assay (HT-RNA-Recruit)...

Abby Thurm @abbythurm Oct 30

Now online at NAR! We’ve added experiments showing how we can sub-classify RNAs into different binding categories that also predict how they will be degraded by RNA down regulatory proteins. An amazing way to finish my PhD :) academic.oup.com/nar/article/54…

academic.oup.com Structural probing of RNA hairpins quantifies protein occupancy on RNA and links it to function in... Abstract. RNA structures that form inside living cells govern processes ranging from translation to RNA decay, many of which are controlled by RNA-binding

Abby Thurm @abbythurm Jan 7

How can we move toward a quantitative, predictive framework for how RBPs bind and regulate their RNA partners? In a new preprint @Cheers2LO @BintuLab, we show that structural profiling via DMS-MaPseq can be used to measure fractional occupancies of RBPs at single-base resolution.
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Abby Thurm @abbythurm Jun 30

Great experience compiling years of collective screening experience to produce what we hope is a comprehensive protocol for others to accessibly scale up experiments! And some fun new data hidden in there :) thanks @JoshTycko for being better and faster at Twitter than me 🎉

Josh Tycko @JoshTycko Jun 30

We hope this protocol is useful for people doing large scale protein function work! nature.com/articles/s4159…

Led by @abbythurm from @BintuLab
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Abby Thurm @abbythurm Jan 7

How can we move toward a quantitative, predictive framework for how RBPs bind and regulate their RNA partners? In a new preprint @Cheers2LO @BintuLab, we show that structural profiling via DMS-MaPseq can be used to measure fractional occupancies of RBPs at single-base resolution.

Abby Thurm @abbythurm Aug 7, 2025

My brilliant, insightful friend @taniafabolous published an op-ed in @Newsweek about her experience as a geneticist watching eugenicist theories exemplified by the Sydney Sweeney ad regain popularity in modern culture. Please read here: newsweek.com/sydney-sweeney…

www.newsweek.com Sydney Sweeney's "Great Jeans" Illuminate Resurgence of Eugenics | Opinion Consumers should stand up for the diversity we want by boycotting companies like American Eagle that reject these values.