Josh Tycko

@JoshTycko

Postdoc at Harvard Med, Greenberg lab & BIDMC, Pollak lab
aka DJ Fishing Expedition

Boston, MA joshtycko.com Joined March 2014

2.7K Following 2.4K Followers 812 Posts

Latest posts 5

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Josh Tycko @JoshTycko Nov 1, 2024

Our new paper on epigenome editing is out!

We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability

nature.com/articles/s4158…

www.nature.com Development of compact transcriptional effectors using high-throughput measurements in diverse... Nature Biotechnology - Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.

Josh Tycko @JoshTycko Oct 20

We still don’t have a complete and current encyclopedia for looking up proteins. Congrats @beccajcarlson & team on this project to organize all the available knowledge on human cell surface proteins!

Becca J. Carlson @beccajcarlson Oct 20

Five major databases of human surface proteins agree on only 188 of them. So we had Claude read the literature instead. Today @deliverome is releasing an open atlas of the accessible human surfaceome, with claims traced directly to quotes from their source 🎯

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Josh Tycko @JoshTycko Jul 20

@NatureBiotech profiled Stylus!

"Stylus is the most advanced, if not the only, ‘LNP durable’ company with transgene expression from a specific genomic site, which minimizes the risk of genotoxicity or secondary malignancy from random insertion."

rdcu.be/fuF2I

Josh Tycko @JoshTycko Jun 30

We hope this protocol is useful for people doing large scale protein function work! nature.com/articles/s4159…

Led by @abbythurm from @BintuLab

www.nature.com High-throughput measurements of protein domain functions using magnetic separation Nature Protocols - This Protocol presents a scalable magnetic separation-based method for screening large protein domain libraries in mammalian cells, providing a simple and quantitative...

Josh Tycko @JoshTycko Jun 15

Can AI find the monkey business in your dataset?