Twitxy Saved

Ajay Nadig

@NadigAjay

md-phd student @harvardmed @mit in @elisebrobinson and @luke0connor labs/ interested in statistical and functional genomics, developmental neuro, heist movies
Boston, MA Joined July 2012
1.1K Following 759 Followers 980 Posts

Latest posts 5

Pinned post

Ajay Nadig @NadigAjay
How often is autism caused by de novo changes to the genome? What is the spectrum of penetrance across autism-associated genes? What can we expect from future autism gene discovery? I'm pleased to share a new preprint where we develop new statistical methods to answer these Qs.
1 replies 21 reposts 61 likes 6.3K views View on X
Ajay Nadig @NadigAjay
Many thanks to @SPeidli for this concise and accessible summary of our recent paper, and how it fits into the broader landscape of statistical methods development for perturbational screens. (link below)
Our paper has been published @NatureGenet! Through new statistical methods, we shed light on fundamental questions about cellular response to genetic perturbations. Our work is a substantial advance towards rigorous characterization and comparison of massive perturbation atlases.
View quoted post on X
1 replies 1 reposts 5 likes 1.8K views View on X
Ajay Nadig @NadigAjay
Our paper has been published @NatureGenet! Through new statistical methods, we shed light on fundamental questions about cellular response to genetic perturbations. Our work is a substantial advance towards rigorous characterization and comparison of massive perturbation atlases.
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
View quoted post on X
6 replies 23 reposts 125 likes 18K views View on X
Ajay Nadig @NadigAjay
this take is overstated, but it’s a virtue of a field to respond to critics generously. unfortunately biologists usually respond by ratio’ing the critic.
Douglas Yao Verified account @DouglasYaoDY Mar 19, 2025
Peter Thiel said that the lack of progress in biology is partially due to a lack of talent.

I think this makes sense. Something about biology's non-technical nature + people's inability to tinker w/biology outside of a lab/PhD make the smartest people select other fields.
View quoted post on X