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Satchin Panda

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@SatchinPanda

Circadian Biologist, Author of the books "The Circadian Code" and "The Circadian Diabetes Code."
La Jolla, California Joined September 2012
105 Following 54K Followers 3.6K Posts

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Satchin Panda Verified account @SatchinPanda
Happy to see the circadian-temperature CAR-T work Adam leads is getting attention.
The core idea came from combining the circadian biology framework my lab had been pioneering with his T-cell expertise.
When he joined my lab in early 2025, there was no dedicated funding for the project. I somehow covered his salary and the full cost of the in vitro, in vivo, and omics experiments in both mouse and human T cells so the work could move forward.
Lab members helped him get up to speed on all experiments, logistics, regulatory issues, and he had priority access to multiple tissue-culture incubators to accelerate the timeline. He also worked evenings and weekends.
The key results and supporting data that open this new direction came within 18 months. Repeating a couple of experiments and publishing the data will let him move into the next phase of his career with a solid foundation.
Salk Institute @salkinstitute Nov 2
Three minutes, one slide, and a winning pitch! Congratulations to Salk postdoctoral researcher Adam Rochussen for taking first place in the Torrey Pines Training Consortium Postdoc Pitch competition.

Cancer immunotherapy rarely takes into account the fact that the cellular environment inside the body is not constant, but rhythmic. Adam found a way to integrate circadian rhythms into next-generation cancer immunotherapies that leads to more effective treatment of multiple cancer types.

The competition challenges postdoctoral researchers from Salk, Sanford Burnham Prebys, Scripps Research, and UC San Diego to explain their research and why it matters in just 180 seconds.

Congratulations, Adam!

#SalkInstitute #PostdocResearch #CancerResearch #ScienceCommunication
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Satchin Panda Verified account @SatchinPanda
Do seabirds get jet lag? 🐦🕐

A new @ScienceMagazine article reports one such rare and once-in-a-lifetime study.
They used 20 years of GPS data collected from 1,045 Manx shearwaters, 3,688 foraging trips, and 1,837 homing flights. 335 of those, flown out of sight of land, were analyzed for clock-driven navigation error. These birds can fly tens to hundreds of km/day foraging over open water.

They found when the birds fly east during the day, their body clock lags local time, and their Sun compass steers them slightly clockwise, as predicted.

They ruled out Coriolis, wind, time of day, distance, colony, flight path type, and a magnetic compass.

But keep it in perspective. A 7° average error adds only ~5 km to a 1,000 km trip home. Real, measurable, and likely harmless. The authors imply no bird returned to the wrong home.

The supplementary text that details the methods and analyses of this complex dataset is worth reading.

I love the paper except their claim that "conserved chronobiological mechanisms impose substantial constraints on navigation". The authors may agree that if the birds did not have a circadian clock, they could not use the sun compass during navigation. So, the last sentence in the summary is a bit overstated.
DOI: 10.1126/science.adz2542
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Satchin Panda Verified account @SatchinPanda
If you track your heart rate, athlete or heart patient or neither, this figure is worth a close look.
It compares six wearables against a reference heart-rate measurement across tens of thousands of readings, from resting to near-max effort.
For the other five devices, 8% to 30% of readings were more than 5 bpm off the reference. That’s roughly 1 in 13 to 1 in 3 readings.
For Temple, it was 2.2%, about 1 in 45.
Study by Temple temple.com/science-and-re…
Deepinder Goyal Verified account @deepigoyal Nov 1
Temple is the most accurate HR tracker compared to all flagship wearables, even in Zone 4 & 5.

Detailed study here: t.pw/hr

temple.com
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Satchin Panda Verified account @SatchinPanda
A hidden gem in our exercise atlas: base-resolution single-nucleus DNA methylation maps of three muscle types, across male and female, sedentary and exercised mice. It’s the first resource of its kind in exercise research. Thank you @JoeEcker
One outcome is a set of cell-type-specific methylation markers. For example, the long noncoding RNA LncPPARa is hypomethylated in progenitor cells.
Look up the methylation signature of your favorite gene here: neomorph.salk.edu/mouse-hpa/mous…
@WuTsaiAlliance @GeraldineMaier
cell.com/cell/abstract/…
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Satchin Panda Verified account @SatchinPanda
To separate chronic from acute effects, we also gave mice just 3 days of voluntary wheel running. The acute and chronic responses overlapped but weren’t identical. Notably, acute exercise triggered stress and inflammation signatures that were attenuated after chronic training. Thanks to @GeraldineMaier @RosmalenLaura and Suraj Pathak.
@WuTsaiAlliance cell.com/cell/abstract/…