Now out in @cellcellpress.bsky.social! A collaborative effort between the Global Microbiome Conservancy, @broadinstitute, and @MGBResearchNews's CCIB to investigate how industrialization shapes the evolutionary trajectories and adaptive potential of gut commensals.
Xavier Lab
@TheXavierLab
Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity. broadinstitute.org/xavier-lab
194 Following 3.1K Followers 592 Posts
Latest posts 5
Excited to share this study in @CellCellPress with @mathildpoyet, @mgroussi and @ejalm, exploring how industrialization shapes host-microbiome interactions using multivariate data from the Global Microbiome Conservancy cohort!
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
We are deeply saddened to learn of Jon Clardy’s passing. He will be remembered for his brilliant work that combined searching for impactful novel molecules, whether in the wilds of the Amazon or in the human gut microbiome...
Jon Clardy: 1943-2026View quoted post on X
One of the most impactful, creative, and (quietly) irreverent practitioners of chemical biology. Transformed how we think about nature's chemicals: their structures, their role in biology. Loved him -- he had tremendous influence on my thinking.
Learn how we developed GPCR‑seq, a multiplexed GPCR screening platform, and uncovered gut microbial products able to activate intestinal receptors that trigger serotonin release or link to #IBD – online now @cellhostmicrobe!
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
New paper in @NatureMedicine with @KimmieNgMD and @AnaAndersonlab! Early-onset colorectal cancer (#EOCRC) is rising. Our single-nucleus atlas of 189 tumors reveals age-associated differences and offers a resource for further research.
nature.com/articles/s4159…
nature.com/articles/s4159…
More people younger than 50 are being diagnosed with colorectal cancer, and the disease is often more aggressive. A single-cell study of colorectal tumors reveals differences in cell composition and expression in tumors from younger patients. broad.io/single-cell-co…View quoted post on X