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Tim Welsh

@TimWelsh_

PhD candidate investigating protein phase separation and other small scale phenomena | @knowleslabcamb @Cambridge_Uni
Cambridge, England Joined October 2020
88 Following 102 Followers 28 Posts

Latest posts 5

Tim Welsh @TimWelsh_
Our paper on the digital sensing of protein:aptamer interactions is finally published! One platform shows the ability to sense everything from single proteins up to biomolecular condensates and exosomes, while elucidating many biophysical parameters. Congrats to all authors!
Georg Krainer @GeorgKrainer Feb 7, 2023
📢 Finally out now: Our paper describing DigitISA, a platform for direct digital sensing of protein biomarkers in solution 🧪 (incl. antibodies, amyloid aggregates & condensates). @KnowlesLabCamb @ChemCambridge Take a look: 👇nature.com/articles/s4146…
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Tim Welsh @TimWelsh_
When theorists and experimentals collaborate good things happen @DaoyuanQian219. Excited to share our work on the measurement and mechanistic insights of tie-lines in biomolecular phase diagrams. Also, maybe we should stop calling PEG an "inert crowder"?

biorxiv.org/content/10.110…
www.biorxiv.org Tie-lines reveal interactions driving heteromolecular condensate formation Phase separation of biomolecules can give rise to membrane-less organelles that contribute to the spatiotemporal organisation of the cell. In most cases, such biomolecular condensates contain...
Tim Welsh @TimWelsh_
Super happy to have contributed to this fantastic piece of work investigating the underlying nucleation mechanisms in solutions of phase separating proteins!

biorxiv.org/content/10.110…
www.biorxiv.org Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated... Macromolecular phase separation is thought to be one of the processes that drive the formation of membraneless biomolecular condensates in cells. The dynamics of phase separation, especially at low...
Tim Welsh @TimWelsh_
Excited to share our recent work in @NanoLetters investigating the electrostatic forces that stablize protein condensates!

pubs.acs.org/doi/abs/10.102…

Thanks to my amazing co-authors @GeorgKrainer, Jorge, @jerelleaj, @rcollepardo and more for their hard work!

@KnowlesLabCamb
pubs.acs.org Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates Abstract. Liquid–liquid phase separation underlies the formation of biological condensates. Physically, such systems are microemulsions that in general hav