ITMAT

@UPENN_ITMAT

ITMAT was launched formally in January 2005; the first Institute of Translational Medicine And Therapeutics in the world.

Philadelphia, PA Joined April 2024

153 Following 97 Followers 313 Posts

Latest posts 5

ITMAT @UPENN_ITMAT 22h

#Inflammation, #OxidativeStress, #MetabolicDysfunction, #GutMicrobiota #Dysbiosis proposed as candidates of excessive #CardiovascularRisk in childhood #ChronicKidneyDisease doi.org/10.1007/s00467… #KidneyDisease #Metabolomics #TranslationalScience

link.springer.com Gene–metabolite–cardiac associations in the Chronic Kidney Disease in Children (CKiD) study Pediatric Nephrology - Characterizing gene–metabolite–cardiac associations in childhood chronic kidney disease (CKD) has the potential to identify new research directions or therapeutic...

ITMAT @UPENN_ITMAT 5d

#BrainRegion specific #transcriptional & #PostTranscriptional responses to #Electroconvulsive stimulation in #MouseBrain #SpatialTranscriptomics nature.com/articles/s4159… @QiQiu8788 @hao_wu_7 #spatialNTseq #TranslationalScience

www.nature.com Spatial mapping of RNA turnover kinetics in the mouse brain Nature Neuroscience - The authors developed spatial NT-seq to map the landscape of RNA turnover and stability regulation in the mouse brain, identifying the dentate gyrus as a turnover hotspot and...

ITMAT @UPENN_ITMAT Nov 3

Expanding #SeizureForecasting: brain clock neurons modulate daily #Seizure susceptibility in #FruitFly model of #Epilepsy doi.org/10.1038/s41467… @amitaseh @chronosleepinst #Drosophila #Neuroscience #TranslationalScience

www.nature.com Clock neurons modulate seizure timing through a diurnal switch Nature Communications - Neural mechanisms that drive diurnal oscillations in seizure susceptibility are not fully understood. Here, in this manuscript, fruit flies show the daily rhythm of seizure...

ITMAT @UPENN_ITMAT Oct 29

Uncovering novel therapeutic strategy for targeting #BranchedChainAminoAcid #Transamination to sensitize #ClearCellRenalCellCarcinoma to #Glutaminase inhibition doi.org/10.1158/0008-5… @AranyLab #ccRCC #KidneyCancer #TranslationalScience

aacrjournals.org Targeting Branched-Chain Amino Acid Transamination Sensitizes Clear Cell Renal Cell Carcinoma to... Abstract. Metabolic reprogramming is a well-described hallmark of clear cell renal cell carcinoma (ccRCC). Gene copy number variation and altered gene expression data suggest enhanced branched-chain...

ITMAT @UPENN_ITMAT Oct 27

Identifying ROR2 (receptor tyrosine kinase-like orphan receptor 2) as promising #DrugTarget to treat #RightVentricularFailure doi.org/10.1161/CIRCUL… #RVfailure #HeartFailure #Proteostasis #TranslationalScience

www.ahajournals.org ROR2 Drives Right Ventricular Heart Failure Through Disruption of Proteostasis | Circulation BACKGROUND: No therapies exist to reverse right ventricular failure (RVF), and the molecular mechanisms that drive RVF remain understudied. We recently reported that the developmentally restricted...