Hao Wu | 吴昊

@hao_wu_7

Epigenetics, gene regulation and time-resolved single-cell & spatial genomics @PennGenetics, @PennEpiInst, @IRM_UPenn

Philadelphia, PA wulabupenn.org Joined November 2014

1K Following 1.6K Followers 528 Posts

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Hao Wu | 吴昊 @hao_wu_7 Sep 2

Excited to share spatial NT-seq, now out @NatureNeuro! By distinguishing newly synthesized from pre-existing RNA, this method turns static snapshots of total RNA into spatially resolved views of RNA life cycles. @PennGenetics @PennEpiInst @PennMedCSO
nature.com/articles/s4159…

www.nature.com Spatial mapping of RNA turnover kinetics in the mouse brain Nature Neuroscience - The authors developed spatial NT-seq to map the landscape of RNA turnover and stability regulation in the mouse brain, identifying the dentate gyrus as a turnover hotspot and...

Hao Wu | 吴昊 @hao_wu_7 Aug 28, 2023

Thrilled to see our single-cell DNA (hydroxy)methylome sequencing method out (rdcu.be/dkAMG) ! Interdisciplinary efforts from talented first authors: @ebfabyanic (Emily's thesis project), Peng - @PengHu_xqq, and Qi - @QiQiu8788 !

Nature Biotechnology Verified account @NatureBiotech Aug 28, 2023

Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects go.nature.com/3Eg2DHu

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Hao Wu | 吴昊 @hao_wu_7 Jun 16, 2023

Awesome work from @KohliLab & @twang0518 !

GenomeTDCC @GenomeTDCC Jun 15, 2023

📢Direct Enzymatic Sequencing of 5mC at Single-Base Resolution - out today in @nchembio
👉nature.com/articles/s4158…
@KohliLab and lead author @twang0518 discuss a new method, DM-seq, to specifically map ONLY 5mC through enzymatic approaches
#genome #sequencing #innovations

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Hao Wu | 吴昊 @hao_wu_7 Apr 19, 2023

Comprehensive profiling of DNA methylome and 3D chromatin structure in single cells across whole mouse brain regions!

Hanqing Liu @Hanq_Liu Apr 18, 2023

Thrilled to share our latest work from @JoeEcker lab, using cutting-edge snmC-seq3 and snm3C-seq technologies to generate 301,626 methylomes and 176,003 mC+3C multiome profiles from 117 dissected regions throughout the adult mouse brain. (1/n)
biorxiv.org/content/10.110…

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Hao Wu | 吴昊 @hao_wu_7 Apr 17, 2023

Take note of this great work from @kamberovlab, which is led by @dingwallaby. Feeling proud to be part of this amazing collaboration with my colleagues @PennGenetics.

kamberovlab @kamberovlab Apr 17, 2023

Our "coolest" new preprint is up! Classic genetics + single transcriptomics = a novel niche and a recipe for identity of the eccrine gland...humans' indispensable thermoregulatory organ. Congrats @dingwallaby and all the team! biorxiv.org/content/10.110…

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