X David Li Lab

@XDavidLiLab1

Professor in HKU Department of Chemistry，School of Biological Science and School of Biomedical Science. Epigenetics and Chemical Biology.

Hong Kong xianglilab.com Joined February 2021

204 Following 667 Followers 159 Posts

Latest posts 5

X David Li Lab @XDavidLiLab1 Jan 9

We have reported a series of first-in-class inhibitors for YEATS domain proteins since 2018, including an ENL inhibitor in 2018, an AF9 inhibitor in 2020, and now the first YEATS2 inhibitor. This work is now published in @nchembio
nature.com/articles/s4158…

X David Li Lab @XDavidLiLab1 Jul 21, 2025

Tenure-Track Professoriate Position in Chemical Biology at The University of Hong Kong
nature.com/naturecareers/…

www.nature.com Tenure-Track Professoriate Position in Chemical Biology - Hong Kong (HK) The University of Hong Kong Tenure-Track Professoriate Position in Chemical Biology (Ref.: 532542) The Department of Chemistry at The University of...

X David Li Lab @XDavidLiLab1 Jun 11, 2024

Congrats to Shixian @Linlab_ZJU on this paradigm-shiftimg work. Unnatural amino acid incorporation using rare codons. Really COOL!!

Shixian Lin Verified account @Linlab_ZJU Jun 7, 2024

🔊Check out our work in @ScienceMagazine. We identify a new weak point (TCG codon) in the codon table of mammalian cells and recode it into non-canonical amino acids (ncAAs) with impressive efficiency and selectivity. This strategy, rare codon recoding (RCR), is very different!

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X David Li Lab @XDavidLiLab1 May 18, 2024

A new application of photo-ANA to interrogate tissue-specific protein-protein interactions is now published in PNAS.

MACSPI enables tissue-selective proteomic and interactomic analyses in multicellular organisms | PNAS pnas.org/doi/10.1073/pn…

X David Li Lab @XDavidLiLab1 Jan 27, 2023

How long and how much it takes from idea to publication?

Here is my tale of three molecules that I designed more than 11 years ago.

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X David Li Lab @XDavidLiLab1 Mar 30, 2024

I am honored to receive this recognition from HKU, where I studied and have served for more than 12 years😊

The University of Hong Kong Verified account @HKUniversity Mar 28, 2024

Congrats to Prof David Li (@XDavidLiLab1) from @HKU_Chemistry and Prof Stephanie Ma (@stephaniema912) from @hkusbms on being awarded this year's #HKU Outstanding Researcher Award for their exceptional research accomplishments!

🎥youtube.com/watch?v=9g1axQ…
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