ZhuangLab

@ZhuangLab

Xiaowei Zhuang's Lab at Harvard University and Howard Hughes Medical Institute

Cambridge, MA 02138 zhuang.harvard.edu Joined November 2024

1 Following 544 Followers 14 Posts

Latest posts 4

Excited to share our recent paper (doi.org/10.1016/j.cell…)! In this multi-year effort, we developed RT&T-AMP-MERFISH, enabling whole-transcriptome-scale, isoform-resolved single-cell spatial transcriptomics and imaging ~33,000 RNAs in the brain.

ZhuangLab @ZhuangLab May 30

What is the global structure of cell-state space—and how do perturbations drive transitions within it?

Excited to share our new preprint (biorxiv.org/content/10.648…), a work in collaboration with @JswLab.

ZhuangLab @ZhuangLab Nov 25, 2024

Delighted to share this preprint from Prof. Rong Fan Lab @RongFan8 and Prof. Sidi Chen lab @sidichen on Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT. Congatulations, Alev, Xiaolong, Feifei, Paul, Sidi and Rong!

Rong Fan @RongFan8 Nov 25, 2024

Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to @AlevBaysoy, Xiaolong, Feifei, and Paul. & collaboration with @sidichen, Hongbo Chi.
biorxiv.org/content/10.110…
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ZhuangLab @ZhuangLab Nov 25, 2024

Check out our preprint on Perturb-multi (doi.org/10.1101/2024.1…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.

William Allen @weallen1 Nov 21, 2024

In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.

Check it out!
biorxiv.org/content/10.110…
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