@mischellab
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Extrachromosomal DNA (ecDNA) are small rings of DNA that help tumours evolve and evade treatment.
The eDyNAmiC team will look at ways to interfere with ecDNA, slow down tumour development & ultimately bring hope to patients whose cancers have become resistant to treatment.
4/6View quoted post on X
Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s4158…View quoted post on X
www.cell.com Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug Bi et al. reveal an actionable lipid vulnerability in GBM that can be exploited with a safe, highly brain-penetrant, FDA-approved drug. They show that fluoxetine kills GBMs by blocking acid sphingo... We are delighted to welcome extrachromosomal DNA pioneer Paul Mischel @mischellab to ChEM-H! Mischel spoke to us about looking where the light isn’t being shone and how genetic SpaghettiOs give cancers an advantage: stanford.io/3ii7BJj
@StanfordPath @StanfordMedView quoted post on X
