Nick Norwitz MD PhD

It’s hard for some people to understand why I did an MD at Harvard and a PhD at Oxford, then chose not to become a conventional doctor. Here’s my why.

And if you or someone you know feels lonely or underserved by conventional medicine, these 10 min might be worth your time. 🙏

This Brownie Lowered My Blood Sugar (By Accident)

1/5) Here's what happened. 🧵🍫

While researching nitric oxide (NO) biology and trying to formulate a brownie that would increase blood flow, I created something that decreased my blood sugar.

85 → 75 → 73 mg/dL.

I tried it again and saw the same strange effect, with my sugars dropping into the 60s.

No spike and dip. Just a smooth down-curve...

What a week at @EudemoniaSummit!

Podcasts. Panels. Brain mapping. Donating bodily fluids to science. And I was touched my talk ended up standing room only. I had a blast, and hope you all did too. ❤️

One of the greatest joys of building StayCurious Metabolism has been connecting with so many of you.

And this week, I had the pleasure of turning some of those online connections into real-life friendships.

The community is exploding. And the curiosity is contagious. Grateful for every one of you.

#StayCurious! This is only the beginning

An extra-special thanks to one of my best friends in the world, @realDaveFeldman. And @reallyoptimized, for being an absolute joy. @drwilliamli and @DavidPerlmutter for being incredible podcast hosts; and the amazing members of my team who joined me, lifted me up, and supported me throughout this event @Flinndustries and Athena Nash. Some of them also helped me navigate a few personal rough patches that I won't get into here, but their kindness and support meant more than they know. I'd be nothing without my friends, family, and this incredible community. Truly grateful for all of you. ❤️

Exercise is good for you. However, it is also a stressor that can be optimized.

And if you don't optimize, high-volume exercise can contribute to increased total and calcified plaque.

🔗 staycuriousmetabolism.substack.com/p/is-your-exer…

Today, we break down the science behind:
💪Exercise & CAC scores
💪Hidden high blood pressure
💪Inflammation
💪Coronary collaterals
💪And more

This kind of science could literally save a life. In fact, it might have saved my dad's.

Why do high-volume athletes have higher CAC scores? 🫀🧵

1/4) This is one of the most interesting paradoxes in heart health.

High-volume endurance athletes tend to have higher, not lower, coronary artery calcium (CAC) scores.

For example, in one study, people who exercised >2,000 MET-minutes per week had a significantly higher risk of having an elevated CAC score.

The question is: Why? And what does it mean?