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rowansci.com Screening Conformer Ensembles with PRISM Pruner Guest blog post from Nicolò Tampellini, discussing efficient pruning of conformational ensembles using RMSD and moment of inertia metrics. 
pubs.acs.org Enantiocontrolled Cyclization to Form Chiral 7- and 8‑Membered Rings Unified by the Same Catalyst... Abstract. Chiral medium-sized rings, albeit displaying attractive properties for drug development, suffer from numerous synthetic challenges due to difficu It's finally time to share this: my long time obsession with inherently chiral medium-sized rings now has a catalytic, enantioselective method. After a number of attempts, we developed a strategy based on choosing the maximally preorganized disconnection, which... [1/3]View quoted post on X
A final frontier of asymmetric #organocatalysis : Catalytic asymmetric fragmentation of cyclopropanes @ScienceMagazineView quoted post on X
science.org/doi/10.1126/sc…
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