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Paul Kohlhaas bio/acc

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@paulkhls

building the scientific singularity / founder & ceo @bioprotocol @molecule_sci pioneering @peptai_ @vitadao / alum @Consensys @AfrikaBurn @HSGStgallen capri ♑️
0 bio.xyz Joined January 2016
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Paul Kohlhaas bio/acc Verified account @paulkhls
Why should access to protein design depend on someone else’s cloud?

Our @biosdiscovery team brought RFD4-Proteina to Mac. Researchers can now generate and screen protein design candidates locally, offline after setup.

The future of science should run on more than a handful of servers
BIOS Verified account @biosdiscovery Nov 3
RFD4-Proteina now runs locally on a MacBook.

Introducing BIOS’s Mac port: generate candidate protein binders and screen their predicted structures locally.

Built with MLX and custom Metal kernels.

• 2.2× faster generation than stock PyTorch-MPS at its default precision
• 20 designs generated and screened → 10 ranked candidates in about 12 minutes on GLP-1R (M5 Pro)

We believe more researchers should be able to run AI experiments on their own hardware. Test ideas locally, keep your research private, and scale to NVIDIA GPUs when you’re ready. After setup, the workflow runs offline.

Watch it run below. ↓
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