Will Chen

@wchenomics

@DamonRunyon Fellow at Baker lab @UWproteindesign. PhD with @JShendure. mainly at bsky.app/profile/chenom…

Seattle, WA chenomics.com Joined October 2013

739 Following 962 Followers 375 Posts

Latest posts 5

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Will Chen @wchenomics Oct 21

Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!

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Will Chen @wchenomics Oct 21

RFD4 is amazing!

Kieran Didi Verified account @DidiKieran Oct 21

Avengers assemble: 1 year BakerLab + NVIDIA GenAIR = 🔥 rfd4-proteina.org

Presenting RFD4-Proteina, our latest protein design model, significantly better and faster than everything we compared against, both in silico and in the lab! 1/30

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Will Chen @wchenomics Oct 8

What a wonderful day for recording community! Such beautiful paired work mapping the lineage from embryo to mouse! Let's decorate some "trees"

Jay Shendure @JShendure Oct 8

Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :)

1. Mouse lineage from E0 to E13.5
science.org/doi/10.1126/sc…
2. A fluctuation test for gastruloid heterogeneity
cell.com/cell/fulltext/…

Paper #1 covered in quoted thread. More on paper #2 here. 1/n
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Will Chen @wchenomics Nov 6, 2025

absolutely excited to see @CXchengxiangQIU starting his own lab at Dartmouth! Great adventure awaits!

Chengxiang Qiu @CXchengxiangQIU Nov 4, 2025

Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/

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Will Chen @wchenomics Aug 27, 2025

Congrats @JingchuanLuo. Really novel way to study localized translation.

Jingchuan Luo @JingchuanLuo Aug 27, 2025

I'm thrilled to share our work from @JswLab (sciencedirect.com/science/articl…). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

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